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Showing 5 results for Jafari-Sales
Evaluation of the antimicrobial effects of Glycyrrhiza glabra l. on some gram positive and gram negative pathogenic bacteria in laboratory conditions
Abolfazl Jafari-Sales, Parisa Bolouri,
Volume 6, Issue 4 (12-2018)
Abstract
Background and objectives: Today, due to the increasing antibiotic resistance of bacteria, the use of medicinal plants as a suitable alternative to antibiotics has increased significantly; therefore, in this study, the antibacterial effects of methanolic extracts of Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa and Escherichia coli were evaluated.
 
Methods: In this laboratory research, after collecting plants and confirming its scientific name, extract of Glycyrrhiza glabra L.  Root was prepared by Soxhlet extractor method at concentrations of 20 mg / ml to 400 mg / ml. Then the antimicrobial effects of this extract were investigated using Agar well diffusion and Dilution test methods.
 
Results: The results showed that the methanolic extracts of G.glabra L. in both Agar well diffusion and Dilution test methods had antibacterial effects on the tested bacteria. The highest effect was observed on S.aureus and the lowest effect was observed in P.aeruginosa.
 
Conclusion: According to the above results, it can be expected that the G.glabra L. extract can be used to treat bacterial infections and is a suitable alternative to commonly used chemical treatments for the treatment of infections.
 
Antibacterial effects of methanolic extracts of Reum ribes L. and Hyssopus officinalis on some standard pathogenic bacteria
Javad Sayyahi, Hayedeh Mobaiyen, Behboud Jafari, Abolfazl Jafari-Sales,
Volume 7, Issue 3 (9-2019)
Abstract
Background and objectives: As much as people become aware of the dangerous side effects of synthetic antibiotics, the demand for natural alternatives to these drugs increases. Natural ingredients, lower risk of complications and even have beneficial side effects. The aim of this study was to determine the antibacterial effect of herbs Reum ribes L and hyssop Hyssopus officinalis is on some pathogenic bacteria.
Methods: After collecting and confirming the scientific name, the methanolic extract of R. ribes L. and  H. officinalis  plants was prepared and the antimicrobial effects of the extracts by agar well diffusion and disk diffusion , as well as the determination of The minimum bactericidal concentration and the minimum inhibitory concentration (MIC / MBC)  were dilution test on Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa.
Results: The highest growth inhibitory zone in S. aureus, B. cereus, P. aeruginosa, and E. coli at concentrations of 400 mg / ml, respectively, in the disc method of 13.21, 13.41, 11.2 and10.74 mm and the well method, respectively 13.64, 13.11, 10.67 mm, and 9.38 mm for the R. ribes L extract, and the disc method of 11.74, 10.2, 10.71, and 9.1 mm, and the well method of 12.41, 11.6, 10.2, and 9.9 respectively. 4.3 mm was observed for H. officinalis extract. The results of MBC / MIC showed that the extract of medicinal plants had the highest susceptibility to B. cereus bacteria and the least susceptibility to E. coli.
Conclusion: R. ribes L. and  H. officinalis  plants have significant inhibitory effects on the growth of pathogenic bacteria in vitro. Therefore, it can be expected that these extracts can be used for the treatment of bacterial infections and are a good alternative to the usual chemical treatments for the treatment of infections.
 

Coronavirus Disease 2019 (COVID-19): review study
Abolfazl Jafari-Sales, Homeira Khaneshpour, Mehrdad Pashazadeh, Rozita Nasiri,
Volume 8, Issue 1 (3-2020)
Abstract
On December 31, 2019, the Wuhan-China Health Commission reported a case of pneumonia in the city. The first symptoms began in mid-December 2019. Clinically isolated specimens identified the coronavirus as the cause of the disease. It was first shown as 2019-nCoV, and as the number of victims of the coronavirus crossed the border of thousands of people, the World Health Organization chose the official name COVID-19 for its illness. Although it appears to be of animal origin, it is rapidly transmitting from person to person around the world. The World Health Organization released a statement calling the outbreak of the new Corona virus a Public Health Emergency Situations that poses a threat to the whole world, not just China. In this study highlights how the virus is transmitted, the clinical signs, the laboratory characteristics, the pathogenicity of the virus, Vaccines, and the prevention and control of the spread of the virus.

Antibacterial effects of Thymus vulgaris, Mentha pulegium, Crocus sativus and Salvia officinalis on pathogenic bacteria: A brief review study based on gram-positive and gram-negative bacteria
Behboud Jafari, Abolfazl Jafari-Sales, ‪homeira Khaneshpour‬‏, Salar Fatemi, Mehrdad Pashazadeh, Ali Esmail Al-Snafi, Afsoon Shariat,
Volume 8, Issue 3 (10-2020)
Abstract
Background and objective: In recent years, with the increase in resistance due to the indiscriminate use of synthetic antibiotics, it seems necessary to find alternative drugs that have both antibacterial properties and have the least side effects for humans. The purpose of this study is to review the antibacterial properties of some medicinal plants.
Material And Method In this review study, the content related to the antibacterial properties of Thymus vulgaris, Mentha pulegium, Crocus sativus, and Salvia officinalis were studied within Magiran, SID, PubMed, MEDLINE, Science Direct, Cochrane Library, Google Scholar, EMBASE, and Scopus databases from 1981 to 2019. Previously published specialized articles and systematic meta-analysis were used as a supplementary source for identifying relevant articles.  Finally, data from 46 articles were pooled and analyzed.
Result: Extracts and essential oils of Thymus vulgaris, Mentha pulegium, Crocus sativus, and Salvia officinalis had a good antibacterial properties against a variety of pathogenic bacteria and their infections.
Conclusion: According to the results of this study, the studied plants can be considered as a suitable option for treating infections caused by pathogenic bacteria and helping to Return the sensitivity of antibiotics in these bacteria, and this requires more comprehensive research on medicinal plants.

Antibiotic resistance and blaTEM β-lactamase gene carriage in Pseudomonas aeruginosa isolates from burn patients: A multicenter study in Tabriz, 2024
Aboalfazl Jafari-Sales , Zahra Ghahremani , Aylin Golestani , Mohadeseh Ghorbanpour Koulani Jadid , Kosar Hosseini-Karkaj , Kosar Soleymanpour , Mohammad Mahdi Salek Faramarzi , Mehrdad Pashazadeh ,
Volume 13, Issue 1 (9-2025)
Abstract
Background: A major contributor to hospital-acquired infections, particularly in burn units, is Pseudomonas aeruginosa (P. aeruginosa). Because this bacterium produces extended-spectrum β-lactamases (ESBLs), antibiotic resistance is a significant treatment concern. In this work, P. aeruginosa isolates from burn victims in Tabriz were examined for antibiotic resistance patterns and the presence of the blaTEM gene.
Methods: In this descriptive-cross-sectional study, 100 clinical isolates of P. aeruginosa were collected from patients hospitalized in the burn wards of Tabriz hospitals over a six-month period. Standard biochemical methods were used to identify microorganisms. Antibiotic resistance patterns were assessed by the disk diffusion technique according to clinical and laboratory standards institute protocols. Additionally, the presence of the blaTEM gene was investigated by polymerase chain reaction, and ESBL production was confirmed by the combined disk test.
Results: The highest resistance rates were observed for levofloxacin (97%) and meropenem (92%), while the lowest was for ceftazidime (69%). Furthermore, 58% (58/100) of the isolates were ESBL-positive, half of which (50%, 29/58) carried the blaTEM gene.
Conclusion: The results of this study indicated that P. aeruginosa strains in burn units of Tabriz hospitals exhibited high antibiotic resistance. Half of ESBL-positive isolates carried the blaTEM gene, highlighting the need for continuous monitoring of antibiotic resistance patterns and prudent use of antibiotics.

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