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Showing 3 results for Aging
The Effect of Interval and Continued Trainings with Citrus Aurantium on Pain Threshold and Motor Balance in Elderly Rats
Omidreza Salehi, Mayam Kheirdeh, Fatemeh Farkhaie, Mehdi Noura, Rasoul Jamali Fashi, Abdolali Rakhshanizadeh,
Volume 10, Issue 2 (5-2022)
Abstract

Background and objectives: Aging is a natural phenomenon associated with a decrease in physical fitness factors and increases in chronic pain. The present study aimed to investigate the effect of High Interval Intensity Training (HIIT) and Moderate Intensity Continued Training (MICT) with Citrus Aurantium (CA) consumption on pain threshold and motor balance in elderly rats.
Material and Methods: Forty-nine elderly rats were randomly divided into 1) control, 2) MICT, 3) HIIT, 4) MICT+CA, 5) HIIT+CA, 6) CA and 7) sham groups. Groups 3 and 5 performed HIIT at a speed of 25-25 m/min, and groups 2 and 4 performed MICT at a speed of 25-20 m/min; also, groups 4-6 received 300 mg/kg/day CA peritoneally. The pain and motor balance tests were evaluated using a hot plate and rotarod devices respectively. The Kolmogorov-Smirnov test was used to investigate the normal distribution of findings and one-way ANOVA with Tukey’s post- hoc tests was used to analyze of findings (P≤0.05).
Results: CA, MICT, HIIT, MICT+CA, and HIIT+CA significantly increased pain threshold and motor balance (P<0.05); MICT+CA (P<0.05) and HIIT+CA (P<0.05) significantly increased pain threshold compared to CA, MICT, and HIIT, and HIIT+CA significantly increased pain threshold compared to MICT+CA (P<0.05).
Conclusion: Although CA, MICT, and HIIT alone can enhance pain threshold and motor balance nevertheless it appears that MICT+CA and HIIT+CA have a better effect on the increase of pain threshold, so the effects of HIIT+CA can be higher than MICT+CA.


The effect of six weeks HIIT exercise on the gene expression of some inflammatory and anti-inflammatory markers of hippocampal tissue in aged male Wistar rats
Sara Ghasdi , Mohammad Rami , Abdolhamid Habibi ,
Volume 13, Issue 1 (3-2025)
Abstract
Background: Research has shown that high-intensity interval training (HIIT) is a convenient and time-efficient approach that promotes oxidative capacity. Therefore, this study aimed to investigate the effect of HIIT on the gene expression of some inflammatory and anti-inflammatory markers of hippocampal tissue in aged male Wistar rats.
Methods: In this experimental study, 21 male Wistar rats were divided into three equal groups: 1- control (C), 2- elderly control (EC), and 3- elderly training (ET). After two weeks of adaptation to the laboratory environment, six weeks of HIIT were performed for the training group. Forty-eight hours after the last training session, hippocampal tissue was isolated to examine the mean levels of interleukin-10 (IL-10), IL-6, and IL-1β gene expression. One-way analysis of variance and Tukey's post-hoc test with a significance level of 0.05 were used to analyze the data.
Results: There was a significant increase in the expression of IL-6 and IL-1β, while a significant decrease in IL-10 expression (p=0.001) in the C group compared to the EC. After six weeks of HIIT, expression of IL-6 (p=0.001) and IL-1β (p=0.001) significantly decreased, whereas IL-10 expression significantly increased (p=0.001) in the ET group compared to the EC group.
Conclusion: It seems that HIIT activity has beneficial effects on preventing the process of neural degeneration. Moreover, it is promising as a non-pharmacological strategy for controlling complications resulting from the aging process due to its anti-inflammatory properties.

Diagnostic accuracy of cardiac CT attenuation for anemia detection and severity grading
Somayeh Livani , Mohammad Mohajertabrizi , Asma Razman , Mitra Omrani ,
Volume 13, Issue 4 (12-2025)
Abstract
Background: Anemia is a prevalent hematological disorder associated with substantial morbidity among hospitalized patients. This study aimed to evaluate the diagnostic accuracy of non-contrast cardiac computed tomography (CT) attenuation measurements obtained from different cardiac regions for detecting anemia and grading its severity.
Methods: This cross-sectional study included 336 patients who underwent non-contrast thoracic CT imaging. Attenuation values were measured in the left ventricle, right ventricle, interventricular septum, and aortic arch and were compared with hemoglobin levels obtained from complete blood count tests. ROC curve analysis, independent-samples t-tests, Mann-Whitney U tests, one-way ANOVA, and correlation analyses were performed to evaluate diagnostic performance and subgroup differences. Significance was set at P-Value < 0.05.
Results: Aortic arch attenuation demonstrated the highest diagnostic accuracy for overall anemia detection (Area under the curve [AUC] = 0.668; Sensitivity = 71.3%; Specificity = 55.9%), followed by left ventricular attenuation (AUC = 0.635; Sensitivity = 44.0%; Specificity = 76.5%). Diagnostic performance improved for moderate to severe anemia (AUCs ranging from 0.690 to 0.757), whereas discrimination of mild anemia remained limited (AUCs ≤ 0.589). Attenuation values in the left ventricle, right ventricle, and aortic arch showed significant inverse correlations with hemoglobin levels (Spearman’s rho = -0.275 to -0.297; P-Value < 0.001), while no significant association was observed in the septum. Gender-stratified analyses showed consistent reductions in attenuation among anemic patients of both genders.
Conclusion: Non-contrast cardiac CT attenuation measurements showed statistically significant associations with hemoglobin levels but demonstrated limited discriminatory performance for anemia detection, particularly in mild cases. Attenuation values obtained during routine thoracic imaging may provide complementary opportunistic information; however, further validation studies are required before clinical implementation.
 

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