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Showing 3 results for Hippocampus
The effect of eight weeks of high-intensity interval training with spirulina supplementation on apoptotic markers in the hippocampal tissue of high-fat diet-induced obese rats
Soraya Pourasghari Siah Astalkhi , Seyed Morteza Tayebi, Lida Moradi, Rasoul Eslami,
Volume 12, Issue 3 (12-2024)
Abstract
Background: Obesity leads to neuronal apoptosis and cognitive impairment by increasing inflammation and oxidative stress. Although the beneficial role of exercise and antioxidant supplements have been reported separately, their interactive effect on neuronal apoptosis in obesity is still not well known. Therefore, this study aimed to investigate the effect of eight weeks of HIIT with Sp supplementation on apoptotic markers in the hippocampal tissue of high-fat diet-(HFD) induced obese rats.
Methods: In this experimental study, 24 obese male Sprague-Dawley rats (60% fat, 20% protein, and 20% carbohydrates) were randomly divided into four groups of six rats, including 1) HFD, 2) HFD+Sp, 3) HFD+HIIT, and 4) HFD+HIIT+Sp. Also, six healthy rats were selected as the HC group to investigate the effects of HFD on research variables. Subsequently, HIIT was performed for eight weeks, three sessions per week with an intensity of 80-110% of maximum running speed and 2-8 high-intensity intervals. Also, Sp supplement was taken orally during this period with a dose of 100 mg/kg/day. Bax and BCL-2 levels were measured with qRT-PCR method. One-way analysis of variance and Tukey's post-hoc tests were used for statistical analysis of data (p ≤0.05).
Results: In the HFD+HIIT and HFD+HIIT+Sp groups, Bax levels and Bax/BCL-2 ratio were lower and BCL-2 levels were higher than the HFD group (p=0.001). In the HFD+Sp group, BCL-2 levels were higher and Bax/BCL-2 ratios were lower than HFD group (p=0.008). Also, in the HFD+HIIT and HFD+HIIT+Sp groups, Bax levels and Bax/BCL ratio were lower and BCL-2 levels were higher than HFD+Sp group (p≤0.05). In addition, in the HFD+HIIT+Sp group, Bax levels were lower and BCL-2 levels were higher than in the HFD+HIIT group (p≤0.05).
Conclusion: It seems that although HIIT and Sp supplement separately have an anti-apoptotic effect, their interactive effect on inhibiting neuronal apoptosis in brain tissue in obesity conditions is more obvious than the effect of each one alone.
 

Investigation of the effect of six weeks of swimming on the caspase-1, TGF-β1, and IFN- γ protein content in the hippocampal tissue of rats with multiple sclerosis
Ali Esmaeili , Abdolhamid Habibi , Mohammad Rami , Mehrzad Shabani ,
Volume 13, Issue 1 (9-2025)
Abstract
Background: Performing exercise training with various protocols, especially aquatic exercises, can be effective against the harmful effects of Multiple Sclerosis. Therefore, the present study aimed to investigate the effect of six weeks of swimming training on the Caspase-1, TGF-β1, and IFN-γ protein content in the hippocampal tissue of rats with Multiple Sclerosis.
Methods: Twenty-one Wistar rats were divided into three equal groups: (1) Healthy control, (2) Multiple Sclerosis control, and (3) Multiple Sclerosis swimming. After two weeks of adaptation to the laboratory environment, the Multiple Sclerosis groups were induced by adding cuprizone to their diet. Six weeks of swimming training were then performed. Forty-eight hours after the last session, hippocampal tissue was isolated to examine Caspase-1, TGF-β1, and IFN-γ protein content. To analyze the data, one-way analysis of variance was used with a significance level of 0.05.
Results: Findings showed that the induction of Multiple Sclerosis in rats caused a significant increase in TGF-β1 and Caspase-1 protein content (P-Value=0.001) and a significant decrease in IFN-γ (P-Value =0.001). After six weeks of swimming, there was a significant decrease in Caspase-1 (P-Value =0.001) and a significant increase in IFN-γ (P-Value =0.001) protein content; however, there was no significant decrease in TGF-β1 protein content (P-Value =0.1).
Conclusion: Based on the findings of this study, it can be concluded that swimming, as a non-pharmacological intervention, has a protective effect on nerves by reducing factors related to inflammation and cell death, which may have beneficial effects on memory information processing in Multiple Sclerosis disease.
 

The effect of six weeks HIIT exercise on the gene expression of some inflammatory and anti-inflammatory markers of hippocampal tissue in aged male Wistar rats
Sara Ghasdi , Mohammad Rami , Abdolhamid Habibi ,
Volume 13, Issue 1 (9-2025)
Abstract
Background: Research has shown that high-intensity interval training (HIIT) is a convenient and time-efficient approach that promotes oxidative capacity. Therefore, this study aimed to investigate the effect of HIIT on the gene expression of some inflammatory and anti-inflammatory markers of hippocampal tissue in aged male Wistar rats.
Methods: In this experimental study, 21 male Wistar rats were divided into three equal groups: 1- control (C), 2- elderly control (EC), and 3- elderly training (ET). After two weeks of adaptation to the laboratory environment, six weeks of HIIT were performed for the training group. Forty-eight hours after the last training session, hippocampal tissue was isolated to examine the mean levels of interleukin-10 (IL-10), IL-6, and IL-1β gene expression. One-way analysis of variance and Tukey's post-hoc test with a significance level of 0.05 were used to analyze the data.
Results: There was a significant increase in the expression of IL-6 and IL-1β, while a significant decrease in IL-10 expression (p=0.001) in the C group compared to the EC. After six weeks of HIIT, expression of IL-6 (p=0.001) and IL-1β (p=0.001) significantly decreased, whereas IL-10 expression significantly increased (p=0.001) in the ET group compared to the EC group.
Conclusion: It seems that HIIT activity has beneficial effects on preventing the process of neural degeneration. Moreover, it is promising as a non-pharmacological strategy for controlling complications resulting from the aging process due to its anti-inflammatory properties.

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